Bruce Levine, Barbara and Edward Netter Professor in Cancer Gene Therapy at the University of Pennsylvania, shared a post on X about a recent article by Sofía Castelli et al, adding:
“Report of note: IL-9 signaling redirects CAR T cell fate toward CD8+ memory and CD4+ cycling states, enhancing antitumor efficacy
- Engineering CAR T cells with IL-9 signaling boosts efficacy against solid tumors
- IL-9-signaling CD4+ CAR T cells have increased Th1 and proliferative phenotypes
- Single-cell profiling reveals that IL-9 redirects CD8+ T cell fate away from dysfunction
- IL-9-induced STAT1/STAT4 activation contributes to improved CAR T cell function.”
Title: IL-9 signaling redirects CAR T cell fate toward CD8+ memory and CD4+cycling states, enhancing antitumor efficacy
Authors: Sofía Castelli, Wesley V. Wilson, Ugur Uslu, Amanda V. Finck, Philipp C. Rommel, Charles-Antoine Assenmacher, Sebastian J. Atoche, Mikko Siurala, M. Angela Aznar, Regina M. Young, Carl H. June
Read the Full Article on Immunity
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