Roberto Borea, Postdoctoral Research at Ohio State University Comprehensive Cancer Center-James Cancer Hospital and Solove Research Institute, shared a post on X about a paper he co-authored published on PubMed Central.
“Managing breast cancer in young BRCA carriers women is uniquely complex.
Our review highlights the critical need for a personalized, multidisciplinary approach to optimize treatment, long-term outcomes, and toxicities.
Take-home messages:
- Early genetic testing enables earlier detection, smaller tumors, and better survival
- Fertility and pregnancy can be safely preserved. Evidence supports ART and post-treatment conception in BRCA carriers
- MRI-based surveillance outperforms traditional screening in young patients
- PARPi have significant efficacy in HRD tumors. More data needed for CDK4/6i and ICIs
- Quality of life must guide survivorship care. Managing menopause, bone, and sexual health is integral to long-term wellbeing.”
Title: Early breast cancer in young BRCA carriers: from diagnosis to treatment and survivorship
Authors: Roberto Borea, Luca Arecco, Simone Nardin, Edoardo Chiappe, Chiara Lanzavecchia, Mónica Fragío Gil, Arianna Meacci, Giang Pham Hoang, Luiza Nardin Weis, Luciana de Moura Leite, Valentina Eva Klocker, Pedro Freire, Nicole Brunetti, Lucia Trevisan, Giulia Buzzatti, Stefano Spinaci, Matteo Lambertini
Read the full article on PubMed central.
More posts featuring Roberto Borea on OncoDaily.