American Cancer Society Journals (ACS Journals) shared a post on LinkedIn:
“New Virtual Tumor Board with patient perspective in CA: A Cancer Journal for Clinicians | A patient with newly diagnosed Breast Cancer found to have mosaic TP53 likely pathogenic variant.
In this multidisciplinary evaluation, a 36yo woman with a history of controlled eosinophilic esophagitis, asthma, and dense fibrocystic breasts was referred to Brown University investigators after abnormal screening mammography. She reported recent fatigue and intermittent diarrhea but had a negative colonoscopy and food allergy testing this year.
She completed a comprehensive 76-gene germline genetic test, which revealed tumor protein p53 (TP53) likely pathogenic variant.
Careful assessment and multidisciplinary discussion of varying types of breast tumors, with thoughtful and persistent assessment of concerning genetic findings to confirm a diagnosis, allowed for streamlined decision making and drastically changed the clinical management and future surveillance recommendations with a goal of primary prevention of secondary malignancies for this patient.”
Title: A patient with newly diagnosed breast cancer found to have mosaic TP53 likely pathogenic variant
Authors: Hetal D. Mistry, MacKenzie R. Adams, Charu Taneja, Lauren J. Massingham, Elizabeth H. Dibble, Kara L. Leonard, Jesse Hart, Galina G. Lagos, Mary Anne Fenton
Read The Full Article at CA: A Cancer Journal for Clinicians.
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