Boyi Gan, N.G. and Hellen Hawkins Distinguished Professor and Director, Radiation and Cancer Metabolism Program at The University of Texas MD Anderson Cancer Center, shared a post on LinkedIn:
“Thrilled to share our new paper published in Cell.
In this study, we uncover a previously unrecognized connection between cuproptosis (copper-induced cell death) and anti-tumor immunity. We demonstrate that activating cuproptosis can engage the immune system and overcome resistance to immune checkpoint blockade, revealing a potential therapeutic strategy for immunotherapy-refractory cancers.
This work establishes cuproptosis as an immunologically active form of regulated cell death and highlights new opportunities for cancer immunotherapy.
Congratulations and thanks to all co-authors and collaborators.”
Title: Cuproptosis-immunity crosstalk informs strategy to overcome immunotherapy resistance
Authors: Guang Lei, Zhengze Lu, Zhihao Xu, Chen Braun, David Huo, Jian Gao, Lin Tan, Ting Hong, Shengrong Wu, Mingchuang Sun, Xi Zhao, Qidong Li, Xiong Chen, Yuelong Yan, Hyemin Lee, Chao Mao, Li Zhuang, Li-Ting Ku, Nahum Puebla, Hampartsoum Barsoumian, Jun Yao, Lingzhi Hong, Jianjun Zhang, Hai Tran, Jiun-Kae Jack Lee, Don Gibbons, Ara Vaporciyan, John Heymach, Chunru Lin, Eyal Gottlieb, Mingjian James You, James W. Welsh, Steven H. Lin, Xingxing Zang, Ziyi Li, Boyi Gan
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