Voices
Aumilto Silva: Integrating sTILs Into PREDICT Improves Prognostic Discrimination in Early-Stage TNBC
Aumilto Silva/LinkedIn

Aumilto Silva: Integrating sTILs Into PREDICT Improves Prognostic Discrimination in Early-Stage TNBC

Aumilto Silva, Medical Oncologist, Senior Research Investigator Brazilian Clinical Research Institute, shared. a post on X:

“In a large pooled analysis (n=3,698), integrating stromal tumor-infiltrating lymphocytes (sTILs) into the PREDICT model significantly improved prognostic discrimination in early-stage TNBC. Each 10% increase in sTILs was associated with a ~15% reduction in breast cancer mortality risk.

The updated model (PREDICT_sTILs) demonstrated robust calibration (O/E ~1.0) and discrimination (AUC ~0.74 at 5 and 10 years), with consistent performance across geographic regions.

Clinically, incorporation of sTILs enhances risk stratification, identifying additional low-risk patients who may safely forgo chemotherapy, while refining selection of those most likely to benefit. These findings reinforce the role of immune biomarkers in prognostication and support more individualized, biology-driven treatment de-escalation strategies in TNBC.”

Title: Including tumor-infiltrating lymphocytes into the PREDICT prognostic model for triple-negative breast cancer survival

Authors: Y. Wang, D. Drubay, S.F. Jonas, J. Dixon-Douglas, B. Acs, S. Adams, F. André, S. Badve, G. Bataillon, J.M. Carter, S. Chia, V. Cockenpot, M.A. Colleoni, C. Criscitiello, G. Curigliano, G.M.H.E. Dackus, S. Demaria, C. Denkert, C.H.M. van Deurzen, M.V. Dieci, D. Giardiello, M.P. Goetz, R.J. Gray, M. Hauptmann, N.D. ter Hoeve, K. Jóźwiak, E.A. Koop, V.M.T. de Jong, H. Joensuu, G. Jules-Clément, R. Kammler, P.L. Kellokumpu-Lehtinen, S.B. Kim, M. Kok, M. Lacroix-Triki, M. Lambertini, H.J. Lee, J. Lemonnier, R.A. Leon-Ferre, S. Leung, B. Linderholm, S. Loibl, J.W.M. Martens, T.O. Nielsen, M. Opdam, P. Pharoah, F. Penault-Llorca, M. Piccart, L. Pustzai, N. Riaz, A. Vincent-Salomon, J. Sparano, T. Shimoi, C. Sotiriou, V.J. Suman, A.M. Timmermans, P.J. van Diest, A.C. Voogd, G. Viale, A.C. Wolff, S. Yazaki, M. Yoshida, R. Salgado, S.C. Linn, M.K. Schmidt, S. Loi, S. Michiels

Read the full article.

Aumilto Silva: Integrating sTILs Into PREDICT Improves Prognostic Discrimination in Early-Stage TNBC

PREDICT sTILs: Bringing Immune Biology Into Chemotherapy Decisions for TNBC
Aumilto Silva: Integrating sTILs Into PREDICT Improves Prognostic Discrimination in Early-Stage TNBC

A. C. Wolff A. Vincent-Salomon A.C. Voogd A.M. Timmermans Aumilto Silva B. Acs B. Linderholm Breast Cancer C. Criscitiello C. Denkert C. Sotiriou C.H.M. van Deurzen D. Drubay D. Giardiello E.A. Koop F. André F. Penault-Llorca G Curigliano G. Bataillon G. Jules-Clément G. Viale G.M.H.E. Dackus H. Joensuu H.J. Lee J. Dixon-Douglas J. Lemonnier J. Sparano J.M. Carter J.W.M. Martens K. Jóźwiak L. Pustzai M. Hauptmann M. Kok M. Lacroix-Triki M. Lambertini M. Opdam M. P. Goetz M. Piccart M. Yoshida M.A. Colleoni M.K. Schmidt M.V. Dieci N. Riaz N.D. ter Hoeve P. Pharoah P.J. van Diest P.L. Kellokumpu-Lehtinen R. Kammler R. Salgado R.A. Leon-Ferre R.J. Gray S. Adams S. Badve S. Chia S. Demaria S. Leung S. Loi S. Loibl S. Michiels S. Yazaki S.-B. Kim S.C. Linn S.F. Jonas T. Shimoi T.O. Nielsen TNBC V. Cockenpot V.J. Suman V.M.T. de Jong Y. Wang