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Antonio Calles on Conflicts Between NeoADAURA and FLAURA-2 Results in EGFR-Mutant Lung Cancer
Antonio Calles/ruberinternacional.es
Sep 9, 2025, 05:48

Antonio Calles on Conflicts Between NeoADAURA and FLAURA-2 Results in EGFR-Mutant Lung Cancer

Antonio Calles, Head of the Lung Cancer Unit at Hospital Ruber Internacional, shared a post on X:

“Neoadjuvant chemotherapy adds nothing to osimertinib in terms of ctDNA clearance or pathological responses in resectable EGFR mutant lung cancer (neoADAURA trial).

In my mind, this somehow conflicts with the results from FLAURA -2 in the metastatic setting, where the addition of chemo to osimertinib improves clinical outcomes. Is because different biology (eg., less clonality in smaller tumors?).”

Antonio Calles on Conflicts Between NeoADAURA and FLAURA-2 Results in EGFR-Mutant Lung Cancer

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