Anirban Maitra, Director of the Perlmutter Cancer Center, shared a post on X:
“Two recent studies highlighting the role of stroma-derived plasminogen activator inhibitor proteins (PAI1 and PAI2) creating an immunosuppressive tumor microenvironment in Pancreatic Cancer, via modulation of macrophage composition.”
Title: A stromal PAI1-tPA axis orchestrates immunosuppression in pancreatic cancer
Authors: Tenzin Ngodup, Brynn Elson, Ashley M. Mello, Sean Hannifin, Miranda Liu, Yaqing Zhang, Jiaqi Shi, Yatrik M. Shah, Daniel A. Lawrence, Marina Pasca di Magliano, Kyoung Eun Lee
Title: Plasminogen activator inhibitors orchestrate the immunosuppressive tumor microenvironment in pancreatic cancer
Authors: Chiara Falcomatà, Sebastian Nielsen, Maximilian Schaefer, Bhavya Singh, Alexander Tepper, Divya Chhamalwan, Hunter Potak, Maxime Dhainaut, Gurkan Mollaoglu, Matthew Park, Miriam Merad, Alessia Baccarini, Brian Brown
Other articles about Pancreatic Cancer on OncoDaily.
