Anirban Maitra, Director of the Perlmutter Cancer Center, shared a post on X:
“Tumor-immune-neural circuit disrupts energy homeostasis in Pancreatic Cancer cachexia. Cancer cell derived CSF1 acts on macrophages via CSF1R to promote GDF15 secretion, which then activates sympathetic signaling via GFRAL/RET binding, promoting cachexia.”
Title: Tumor-immune-neural circuit disrupts energy homeostasis in cancer cachexia
Authors: Xiuhui Shi, Alex X. Arreola, Zhijun Zhou, Jingxuan Yang, Mingyang Liu, Yang Cai, Yu Ren, Hao Yuan, Qun Chen, Xinjie Chen, Xinyu Yang, Yimei Meng, Jingyi Wang, Wenyi Luo, Michael C. Rudolph, Rohan Varshney, Kar-Ming Fung, Chao Xu, Wei R. Chen, Michael S. Bronze, Lei Zheng, Yi-Ping Li, Courtney W. Houchen, Yuqing Zhang, Min Li
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