Andrea Sottoriva, Head of the Computational Biology Research Centre at Human Technopole, shared a post on X:
“How stable is chromosomal instability? We followed copy numbers over years in colorectal cancer patients.
Chromosomal instability is high at single cell level, but does not manifest macroscopically, suggesting negative selection of karyotypes.”
Title: Negative Selection Maintains Grossly Altered but Broadly Stable Karyotypes in Metastatic Colorectal Cancer
Authors: William C.H. Cross, Salpie Nowinski, George D. Cresswell, Maximilian Mossner, Abhirup Banerjee, Bingxin Lu, Marc J. Williams, Georgios Vlachogiannis, Laura J. Gay, Ann-Marie Baker, Christopher Kimberley, Frederick J.H. Whiting, Hayley L. Belnoue-Davis, Pierre Martinez, Maria Traki, Viola Walther, Kane Smith, Javier Fernandez-Mateos, Erika Yara-Romero, Erica A. Oliveira, Salvatore Milite, Giulio Caravagna, Chela T. James, George Elia, Alison Berner, Chang-Ho Ryan Choi, Pradeep Ramagiri, Ritika Chauhan, Nik Matthews, Jamie Murphy, Anthony Antoniou, Susan K. Clark, Miriam Mitchison, Jo-Anne Chin Aleong, Enric Domingo, Inmaculada Spiteri, Stuart A.C. McDonald, Darryl Shibata, Miangela M. Laclé, Lai Mun Wang, Morgan Moorghen, Ian P.M. Tomlinson, Marco Novelli, Marnix Jansen, Alan Watson, Nicola Valeri, Nicholas A. Wright, John A. Bridgewater, Manuel Rodriguez-Justo, Chris P. Barnes, Hemant M. Kocher, Simon J. Leedham, Andrea Sottoriva, Trevor A. Graham
Read the full article on Cancer Discovery.
Read more about Colorectal Cancer on OncoDaily.
