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Andrea Boutros: How Does Immunotherapy Affect Male Fertility? 
Aug 27, 2025, 13:56

Andrea Boutros: How Does Immunotherapy Affect Male Fertility? 

Andrea Boutros, Medical Doctor and Oncology Resident at San Martino Polyclinic Hospital, shared on X:

“How does immunotherapy affect male fertility?

A prospective study of 26 men with melanoma receiving ICIs showed only modest declines in sperm output.

New prospective cohort (n=26) of men with melanoma on ICIs: sperm output decreases ~34% and concentration decreases~30%; motility/morphology unchanged; modest FSH increases; T/LH stable; one autoimmune orchitis case.

Should we offer fertility preservation upfront? Read more!

Special thanks.”

Title: Testicular Function After Immune-Checkpoint Inhibitors Treatment

Authors: Andrea Boutros, Amanda Idan, Sue Sleiman, Feyrous Bacha, Ting Zhang, Veena Jayadev, Alexander M. Menzies, Georgina V. Long, David J. Handelsman

Read the full article.

Andrea Boutros