St. Jude Children’s Research Hospital shared a post on LinkedIn:
“St. Jude Children’s Research Hospital has introduced AlphaSync, a database designed to maintain current predicted protein structures as new sequence information becomes available. This resource addresses a longstanding challenge in protein science by ensuring that structural models reflect the latest experimental evidence and sequence data. With AlphaSync, researchers can confidently analyze protein structures, minimizing the risk of errors caused by outdated information.
AlphaSync builds upon the foundation established by AlphaFold2 and the AlphaFold Protein Structure Database, which revolutionized the field by enabling high-accuracy predictions for millions of proteins. However, those resources are not routinely updated, resulting in models that may not represent the most current protein sequences. AlphaSync solves this problem by regularly checking UniProt, the largest protein sequence database, and generating new structural predictions as soon as sequences are added or modified.
‘In a rapidly evolving scientific landscape, having access to the most current and detailed information on protein structural models is essential for breakthroughs in medicine and biology,’ said M. Madan Babu, PhD, FRS, Senior Vice President of Data Science and Chief Data Scientist at St. Jude. ‘With AlphaSync, we ensure predicted protein structures stay continuously updated and enriched with key information such as amino acid interaction networks, surface accessibility and disorder status so that researchers can move from sequence to insight faster than ever before.’
The AlphaSync database offers more than just updated structures. It provides pre-computed data at the amino acid level, including residue interaction networks, surface accessibility and disorder status. Additionally, AlphaSync features a user-friendly interface and a simplified data format, making it easier for researchers to access and analyze information. This approach empowers scientists to perform structural analyses with greater accuracy and efficiency.
The database is freely available and designed to accelerate advances in biomedical research and structural biology.
Learn more about AlphaSync and where to access the database.”
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