Alessandro Gronchi, Director of the Department of Oncological Surgery at the IRCCS Foundation National Cancer Institute of Milan, shared a post on LinkedIn:
“Neoadjuvant RT in primary retroperitoneal WDLPS: time for clarity?
Proud to share our latest work from the Transatlantic Australasian
Retroperitoneal Sarcoma Working Group (TARPSWG), just published in eClinicalMedicine – The Lancet Discovery Science.
In this largest series to date of patients with primary RP well-differentiated liposarcoma (582 patients, 24 centers, 15 years), we specifically addressed a question that has remained controversial after STRASS:
Does neoadjuvant radiotherapy improve local control in pRP-WDLPS?
Using 1:2 propensity score matching, we found:
5-year local recurrence:
- 6% with neoadjuvant RT + surgery
- 26% with surgery alone
8-year local recurrence:
- 10% vs 33%
Neoadjuvant RT was associated with a significant reduction in local recurrence.
No statistically significant OS benefit was observed (yet), but given the long natural history of WDLPS, longer follow-up will be crucial.
These findings:
- Expand on the STRASS exploratory subgroup analysis
- Validate the STREXIT observations
- Strengthen the rationale for a histology-driven approach in retroperitoneal sarcoma
For a disease where distant metastases are negligible and local failure drives morbidity, improving local control matters. As always, decisions must be individualized and discussed in high-volume multidisciplinary sarcoma teams.
I would be very interested to hear:
Has your institution changed practice after STRASS?
Are you routinely offering neoadjuvant RT for pRP-WDLPS?”
Title: Neoadjuvant radiotherapy for primary retroperitoneal well-differentiated liposarcoma: a Transatlantic Australasian Retroperitoneal Sarcoma Working Group (TARPSWG) propensity score matched analysis
Authors: Mark Fairweather, Megan Sulciner, Joshua Jolissaint, Marco Fiore, Dorian Garcia Ortega, Shintaro Iwata, Samuel Forde, Carol Swallow, Eran Nizri, Vittorio Quagliuolo, Carolyn Nessim, Dagmar Adamkova, Piotr Rutkowski, Kenneth Cardona, Edward Kimm, Andrea Porpiglian, Fabian Johnston, David Gyorki, Bruno Vincenzi, Kim-Fuchs Corina, Sonja Kramer, Dan Blazer, William Tseng, Markus Albertsmeier, Jose Antonio González, Daphne Hompes, Elizabeth Baldini, Alessandro Gronchi, Chandrajit Raut
Read the Full Article.
Other articles featuring Alessandro Gronchi.