Ajay Major, Founder and President of Pager Publications and Assistant Professor of Medicine at the University of Colorado School of Medicine, shared a post on X:
“BRUIN final update: pirto MCL ASH25
- 166 patients: 84% refractory prior cBTKi, 9% prior CAR
- Prior cBTKi: ORR 49% (CR 16%), mDOR 22 months
- mPFS 5.6 months, mOS 24 months
- G3+ infx 21%, all-grade afib 4%, 8% G5 AEs
- 43% remain on treatment
cBTKi naive did better overall. Seeking TP53 data.”
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