Ahmet Dirican, Professor of Medical Oncology at Medicana International İzmir Hospital, shared a post on X:
“Can intermuscular fat predict immunotherapy response?
AI-driven analysis in 2,132 NSCLC patients:
92 body composition parameters extracted from CT and integrated with RNA-seq data.
Findings:
- Intermuscular fat (IMFV) – better OS
High IMFV associated with:
- T-cell exhaustion.
- Interferon signaling.
- Immune activation.
Discussion:
Fat is not just storage – it may actively shape anti-tumor immunity.
BMI is not enough. Body composition matters.
This study raises the idea that resistance and endurance exercise may influence immunotherapy response.”
Title: AI-driven body composition atlas reveals its association with NSCLC immunotherapy outcome and molecular background: a multicenter study
Authors: Yusheng Guo, Bingxin Gong, Jie Lou, Li Wan, Ying-Long Peng, Yiqun Chen, Xiaoyan Lei, Peng Mo, Qi Wan, Qing Sun, Shu Peng, Chuansheng Zheng, Lian Yang
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