Achyut Saroj, Founder, Consultant, and Author at AwareOnc, KOL Engagement and Medical Affairs Liaison at Tatva Health, shared a post on LinkedIn:
“Exciting news in the field of oncology and liquid biopsy!
I’m proud to share the latest research published in Nature Cancer: ‘A pan-cancer compendium of 1,294 plasma cell-free DNA methylomes and fragmentomes enabling multicancer detection’.
This study introduces the largest compiled multicancer plasma cfMeDIP-seq dataset to date, featuring 1,294 samples across 11 major cancer types, healthy controls, and individuals with Li-Fraumeni syndrome.
What makes this work a milestone?
- Multimodal Integration: While many studies look at one feature, this study integrated cfDNA methylome and fragmentome features, including 5′ end motifs, fragment ratios, and nucleosome footprints. This synergy significantly enhanced the robustness and accuracy of cancer detection and classification.
- Standardized Workflow: To overcome the challenge of inconsistent data processing in liquid biopsy, the authors developed a uniform computational workflow to mitigate technical and biological batch effects across different cohorts.
- A Single Assay Solution: Study demonstrated that cfMeDIP-seq can capture both methylation and fragmentation signatures in a single assay, which could streamline clinical workflows and reduce costs for large-scale screening.
- Proven Generalization: Findings were successfully validated in an independent set of 220 samples, including cancer types entirely absent from our primary dataset.
This compendium serves as a foundational resource for the scientific community to advance early cancer detection and monitor disease evolution more effectively.
Congratulations to the extensive collaborative team at the University Health Network, University of Toronto, and the Ontario Institute for Cancer Research!”
Title: A pan-cancer compendium of 1,294 plasma cell-free DNA methylomes and fragmentomes enabling multicancer detection
Authors: Yong Zeng, Dor Abelman, Althaf Singhawansa, Nicholas Cheng, Yuanchang Fang, Sasha Main, Emma Bell, Wenbin Ye, Ping Luo, Samantha Wilson, Eric Stutheit-Zhao, Derek Wong, Nadia Znassi, Kui Chen, Suluxan Mohanraj, Enrique Sanz-Garcia, Faiyaz Notta, Anand Ghanekar, Philip Awadalla, Benjamin Lok, Michael Hoffman, Raymond Kim, Gelareh Zadeh, Daniel De Carvalho, Scott Bratman, Mathieu Lupien, Trevor Pugh, Housheng He
Read the Full Article.
Other articles featuring Achyut Saroj on OncoDaily.