Stephen V Liu, Director of Thoracic Oncology, Chief of the Division of Hematology and Oncology, and Associate Professor at Georgetown Lombardi Comprehensive Cancer Center, shared a post on shared a post on X:
“Still learning about resistance to KRAS inhibitors. Case report JTO & JTO CRR describes pt with KRAS G12C adenocarcinoma who responded to sotorasib but at resistance, biopsy showed ERBB3 amplification & pleomorphic histology. Highlights value of rebiopsy.”
Title: Lung Adenocarcinoma Developing Pleomorphic Carcinoma with ERBB3Amplification After Acquired Resistance to Sotorasib: A Case Report
Authors: Satoru Senoo, Kohei Takata, Shunsuke Matsumori, Takahiro Baba, Yuka Sugisaki, Hiroki Omori, Hiroaki Matsuura, Yumi Matsuura, Rika Omote, Eiki Ichihara, Toshiaki Okada
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