Bassam Sonbol, Oncologist at Mayo Clinic Arizona, shared a post on X:
“Grateful for a strong showing at GI26 ASCO, especially the outstanding work led by our trainees- 6 mentored posters (two with Merit Awards from Conquer Cancer, the ASCO Foundation) and 2 presentations. Looking forward to sharing updates from my investigator-initiated ACCRU 1810 study, Modeling analysis from RATIONAL305, LLM performance in CRC, Irbaz Riaz, IO in dMMR gastric cancer, timing of immunotherapy, and more!
ACCRU 1810: This is my investigator-initiated study through ACCRU network. Trying to bring FTD-TPI to second-line so we can get a neuropathy-free combo. PH2 FTD-TPI plus RAM versus TAXOL plus RAM. Study was stopped early. Interesting signal in those with prior IO exposure (data in poster). Poster Board Number: D23. Thursday.”
Title: ACCRU-GI-1810: Trifluridine/tipiracil (FTD-TPI) or paclitaxel (PAC) in combination with ramucirumab (RAM) for patients (pts) with previously treated advanced gastroesophageal adenocarcinoma (GEA) —An investigator-initiated, randomized non-inferiority phase 2 study.
Authors: Mohamad Sonbol, Angela Ulrich, Fang-Shu Ou, Anina Peersen, Daniel Ahn, Jason Starr, Anthony Jaslowski, Arun Nagarajan, Syma Iqbal, Michael Gibson, Tanios Bekaii-Saab
Read the Full Article in ASCO.
“Excited to share modeling analysis of RATIONALE-305: the phase III study of chemo+/- tislilizumab in advanced gastric/GEJ established tisli as SOC in PDL1+ pts. Notably high peritoneal metastasis burden in the trial—here we evaluate the impact of varying PM levels on outcomes with tislelizumab plus chemo. Poster Board D9, Thursday.”
Title: Modeling analysis of RATIONALE-305: Impact of peritoneal metastasis (PM) representation on clinical outcomes in patients (pts) treated with tislelizumab plus chemotherapy (TIS+CT) with gastric cancer/ gastroesophageal junction cancer (GC/GEJC).
Authors: Mohamad Sonbol, Sun Young Rha, Rui-Hua Xu, Filippo Pietrantonio, Markus Moehler, Ken Kato, Maria Alsina, Hyung-Don Kim, Yaling Xu, Xuan Kong, Na Zhao, Sylvie Lorenzen
Read the Full Article in ASCO.
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