Angela Mastronuzzi, Head of Neuro-Oncology Unit at Bambino Gesù Children’s Hospital and President of AIEOP, shared a post on LinkedIn:
” ‘Identification of a miRNAs signature as potential biomarker of mesenchymal phenotype in neuroblastoma patients‘ out with Biomarker Research of Springer Nature
Tumor heterogeneity drives cancer progression and affects drug response, hindering long-term remission. In neuroblastoma (NB), plasticity between MES and ADRN states influences treatment outcomes, impacting treatment response. MiRNAs regulate tumor plasticity and may promote differentiation and chemosensitivity, though their role in NB plasticity remains unexplored.
This study highlights miR-199a-3p as a biomarker of MES phenotype, being related with pathways associated with tumor plasticity, metastasis, and therapy resistance. MiR-199a-3p shows context-dependent roles in cancer but acts as an oncogene in NB.
Our results indicate that miR-199a-3p may contribute to the aggressive behavior of MES NB cells by enhancing proliferation and migration. This suggests its potential as both a biomarker and a therapeutic target. Further investigation is necessary to elucidate its underlying mechanisms and validate its clinical relevance.
We demonstrate that miR-584a-5p carried in plasma derived EVs may serve as potential biomarker of NB aggressiveness. The observed discrepancy – higher levels in EVs but reduced expression in aggressive tumors – supports its tumor-suppressive role. By further elucidating the role of miRNAs in NB plasticity, our findings lay the groundwork for identifying novel biomarkers and therapeutic strategies aimed to improve outcomes for HR-NB patients.
We would like to express our sincere gratitude to the patients who enrolled in this study.”
Title: Identification of a miRNAs signature as potential biomarker of mesenchymal phenotype in neuroblastoma patients
Authors: Silvia Lampis, Alessandro Paolini, Virginia Di Paolo, Angela Galardi, Salvatore Raieli, Evelina Miele, Lauriane Lemelle, Francesco Fabozzi, Annalisa Serra, Angela Mastronuzzi, Maria Antonietta De Ioris, Andrea Masotti, Franco Locatelli, Angela Di Giannatale
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