Yan Leyfman, Medical Oncologist, Co-Founder and Executive Director of MedNews Week, shared a post on LinkedIn:
“Early-Onset Colorectal Cancer Is Rising Fast — The Metabolic Connection
Early-onset colorectal cancer (EOCRC) is climbing worldwide, especially in adults under 50 — tracking closely with rising obesity and type 2 diabetes (T2DM) in younger populations.
Emerging data show that metabolic dysfunction can fuel EOCRC through insulin resistance, chronic inflammation, and gut microbiome disruption — creating a pro-tumor environment earlier in life.
Key Insights
- EOCRC rates are rising globally, aligned with increases in obesity and T2DM among young adults.
- Insulin resistance, inflammation, and microbiome shifts may accelerate early carcinogenesis.
- Western diets high in UPFs, sugars, and saturated fats heighten metabolic risk and EOCRC susceptibility.
- Current screening may miss high-risk young adults; adding metabolic, microbiome, and lifestyle data could refine risk stratification.
- Lifestyle changes, targeted nutrition, physical activity, GLP-1 agonists, and metformin show prevention potential.
- More multi-omics research and RCTs are essential to understand age-specific metabolic pathways and microbial signatures.”
Title: Early-onset colorectal cancer as an emerging disease of metabolic dysregulation
Authors: Mengxi Du, David A. Drew, Marcus D. Goncalves, Yin Cao, Andrew T. Chan
Read the Full Article.
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