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Xiuning Le
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Xiuning Le: Differential Impact of EGFR Exon 20 Insertion Location on TKI Sensitivity

Xiuning Le, Associate Professor, Deputy Section Chief of Thoracic Medical Oncology at MD Anderson Cancer Center, shared a post on X:

“Are we ready for ultra-precision oncology?

New online: Differential impact of EGFR Exon 20 insertion location (near- vs. far-loop) on TKI sensitivity

  • EGFRex20ins can be separated into two distinct groups: near-loop (A767-P772) and far-loop (H773-R776) insertions.
  • Molecular dynamics simulations reveal that near-loop insertions have multiple conformational states and lower transitional energy than far-loop insertions.
  • This leads to differential responses and PFS in some TKIs but not all.

This study highlights how ultra-precision oncology should guide small molecule drug development.”

Title: Poziotinib for EGFR exon 20-insertion NSCLC: Clinical efficacy of the phase 2 ZENITH trial and differential impact of EGFR exon 20 insertion location on sensitivity.

Authors: Xiuning Le, Jacqulyne Robichaux, Monique Nilsson, R. S. K. Vijayan, Ashwin Ravichandran, Jia Wu, Yasir Elamin, Lingzhi Hong, Jun Pei, Jun He, Sonia Patel, Hibiki Udagawa, Sriramvignesh Mani, Chang Woon Jang, Jeffrey Clarke, Nishan Tchekmedyian, Jonathan Goldman, Mark Socinski, Gajanan Bhat, Sharon Leu, Veronica Bunn, Zhenqiang Su, Sylvie Vincent, John Lawson, Jason Cross, John Heymach

Read the full article in Nature Communications.

Xiuning Le

 

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Ashwin Ravichandran cancer Chang Woon Jang EGFR Exon 20 Gajanan Bhat Hibiki Udagawa Jacqulyne Robichaux Jason Cross Jeffrey Clarke Jia Wu John Heymach John Lawson Jonathan Goldman Jun He Jun Pei Lingzhi Hong Mark Socinski Monique Nilsson Nishan Tchekmedyian OncoDaily Oncology R. S. K. Vijayan Sharon Leu Sonia Patel Sriramvignesh Mani Sylvie Vincent Veronica Bunn Xiuning Le Yasir Elamin Zhenqiang Su