Unveiling Scientific Discoveries: The Impact of Liver Transplantation in Epithelioid Hemangioendothelioma
Ignazio Roberto Marino. “Scientific research is fascinating and often unpredictable. I want to provide three examples of something that happened to me that demonstrates that imagination and curiosity are essential in discovering scientific development. Still, possibly, persistence is even more critical. I will show describe here you three of my most cited papers I published during my research activities. Today, I will describe how I demonstrated the successful role of liver transplantation in the epithelioid hemangioendothelioma of the liver. In 1987, the pioneer of liver transplantation, Thomas E. Starzl, asked me to review almost 1,000 liver transplantations performed by his team in Denver and Pittsburgh. Thomas Starzl asked me to focus mainly on the outcome of patients transplanted because of a liver tumor. Several patients underwent liver transplantation with the diagnosis of angiosarcoma. Most of them died shortly after the surgical procedure because of tumor recurrence. Instead, a small group of them were still alive and well, some with a 10-year follow-up. We examined the original pathology again and discovered that the small group of patients doing well did not have an angiosarcoma but an epithelioid hemangioendothelioma. From that moment, this disease became a worldwide indication for treatment with liver transplantation.”
Source: Ignazio Roberto Marino/Linkedin
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