Skoda: clonal evolution of Myeloproliferative Neoplasms

Talha Badar, Assistant Professor at Mayo Clinic Comprehensive Cancer Center shared on X:

“Skoda: clonal evolution of MPN, pre-CHIP—> CHIP—>MPN

1) concurrent mutation e.g. DNMT3A confer resistance to therapy

2) pegIFN most efficient way to decrease mutation allelic burden in MPN

3) pegIFN in combination with AZA may overcome concurrent resistant mutation in MPN.”

Source: Talha Badar/X