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Skoda: clonal evolution of Myeloproliferative Neoplasms
Photo of Radek Skoda from biomedizin.unibas.ch
Jun 18, 2024, 02:57

Skoda: clonal evolution of Myeloproliferative Neoplasms

Talha Badar, Assistant Professor at Mayo Clinic Comprehensive Cancer Center shared on X:

“Skoda: clonal evolution of MPN, pre-CHIP—> CHIP—>MPN

1) concurrent mutation e.g. DNMT3A confer resistance to therapy

2) pegIFN most efficient way to decrease mutation allelic burden in MPN

3) pegIFN in combination with AZA may overcome concurrent resistant mutation in MPN.”

Talha Badar

Talha Badar Talha Badar

Source: Talha Badar/X

AZA cancer CHIP clonal evolution combination therapy concurrent mutation DNMT3A Mayo Clinic Comprehensive Cancer Center MPN MPN treatment mutation allelic burden OncoDaily Oncology pegIFN pre-CHIP resistance to therapy Skoda Talha Badar
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