Jean-Charles Soria: Platelets Can Carry Tumor DNA
Jean-Charles Soria, SVP and Oncology Therapeutic Area Head at Amgen, shared a post on LinkedIn:
” Platelets can carry tumor DNA.
- Platelets – smallest yet 2nd most abundant blood cell type.
- New study: tumor-derived DNA found in platelets of advanced cancer patients.
- This cfDNA reservoir could complement plasma cfDNA, boosting detection sensitivity in low–tumor burden disease.
- Platelets’ ubiquity, rapid turnover and vascular contact make them ideal biosensors for cancer and genetic alterations.
- Findings carry broad implications for Liquid Biopsies and precision oncology.”
Title: Platelets sequester extracellular DNA, capturing tumor-derived and free fetal DNA
Authors: Lauren Murphy, Jeanne Inchauspé, Giampiero Valenzano, Pamela Holland, Nikolaos Sousos, Hayley L. Belnoue-Davis, Rong Li, Natalie J. Jooss, Camelia Benlabiod, Eleanor Murphy, Zohar Etzioni, Emelie Shepherd, Lucy Denly, Sujata Biswas, Lin Chen, Jennifer O’Sullivan, Michael P. Rimmer, Abdullah O. Khan, Christina Simoglou Karali, Nadia Nasreddin, Ian S. Hitchcock, Milka Koupenova, Skirmantas Kriaucionis, Jim R. Hughes, Eric O’Neill, Manu Vatish, Paul Rees, Simon Leedham, Michael Desborough, Adam J. Mead, Benjamin Schuster-Böckler, Christopher D. Gregory, Bethan Psaila
Read The Full Article at Science.
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