Insight

Howard McLeod Shared Results of NCI MATCH Study

Howard McLeod/LinkedIn

Aug 15, 2025, 13:32

Howard McLeod Shared Results of NCI MATCH Study

Howard McLeod, Center Director at Center for Precision Medicine and Functional Genomics, shared a post on LinkedIn:

“The National Cancer Institute (NCI) MATCH study gave an opportunity to assess concordance of comprehensive genomic profiling across 11 commercial and 14 academic laboratories (with the NCI central lab being the standard). As many of us have seen in practice, high concordance for SNV, insert, deletion, and copy number variants in therapeutically relevant driver genes for NGS across the labs (not as good for hybridization capture assays). Gives confidence for using the NGS lab that gives you the genes you need, at the turn around time that is needed.”

Title: A Concordance Study among 26 NGS Laboratories Participating in the NCI Molecular Analysis for Therapy Choice Clinical Trial Available to Purchase

Authors: Linda K. Zane, Laura M. Yee, Ting-Chia Chang, Jeffrey Sklar, Guangxiao Yang, Jia Di Wen, Peining Li, Robin Harrington, David J. Sims, Kneshay Harper, Jeffrey M. Trent, Janine R. LoBello, Szabolcs Szelinger, Kasey Benson, Jia Zeng, Kelsey Poorman, Danbin Xu, Garrett M. Frampton, Dean C. Pavlick, Vincent A. Miller, Bevan Tandon, Wojciech Swat, Lawrence Weiss, Vincent Anthony Funari, Jeffrey M. Conroy, James L. Prescott, Pranil K. Chandra, Charles Ma, Kristen J. Champion, Gregory X. Baschkopf, Yuri A. Fesko, Tracey Allen K. Freitas, Scott A. Tomlins, Daniel H. Hovelson, Kevin White, Shelly Sorrells, Robert Tell, Nike Beaubier, David King, Lei Li, Kevin Kelly, Jasmina Uvalic, Bridgette Meyers, Ravindra Kolhe, Neal I. Lindeman, Michele Baltay, Lynette M. Sholl, Jean Lopategui, Eric Vail, Wenjuan Zhang, Milhan Telatar, Michelle Afkhami, Susan J. Hsiao, Mahesh M. Mansukhani, Emily Adams, LiQun Jiang, for the NCI-MATCH Designated Laboratories, Kenneth D. Aldape, Mark Raffeld, Liqiang Xi, for NCI-COMPASS Team, Henning Stehr, Jeremy P. Segal, Dara L. Aisner, Kurtis D. Davies, Noah A. Brown, Robert J. Livingston, Eric Q. Konnick, Wei Song, James P. Solomon, Zenta Walther, for NCI-MATCH Designated Laboratories, Lisa M. McShane, Lyndsay N. Harris, Alice P. Chen,Gregory J. Tsongalis, Stanley R. Hamilton, Keith T. Flaherty, Peter J. O’Dwyer, Barbara A. Conley, David R. Patton, A. John Iafrate, P. Mickey William, James V. Tricoli, Chris Karlovich

Read The Full Article at AACR Journals.

Howard McLeod