Hung Trinh: The Solid Tumor Microenvironment and Related Targeting Strategies
Hung Trinh, Senior VP of Operations at Seneca Therapeutics, shared a post on LinkedIn about recent paper published in Frontiers:
“The solid tumor microenvironment and related targeting strategies: a concise review
To target TME, it is necessary to deeply understand the role of various components of TME in tumor growth and search for potential therapeutic targets. Herein, we innovatively classify the TME into physical microenvironment (such as oxygen, pH, etc.), mechanical microenvironment (such as extracellular matrix, blood vessels, etc.), metabolic microenvironment (such as glucose, lipids, etc.), inflammatory microenvironment and immune microenvironment.
We introduce a concise but comprehensive classification of the TME; depict the characteristics of each component in TME; summarize the existing methods for detecting each component in TME; highlight the current strategies and potential therapeutic targets for TME; discuss current challenges in presenting TME and its clinical applications; and provide our prospect on the future research direction and clinical benefits of TME.
Title: The solid tumor microenvironment and related targeting strategies: a concise review
Authors: Yingliang Wang, Huimin Zhou, Shuguang Ju, Xiangjun Dong, Chuansheng Zheng
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