Aakash Desai: JTO SUPE_R Trial Sheds Light on Surveillance Imaging for Stage IA-IIIC NSCLC
Aakash Desai, Associate Director of Phase 1 and Precision Oncology Program at UAB O’Neal Comprehensive Cancer Center, shared on LinkedIn about a recent paper by Kasper Foged Guldbrandsen et al. published on JTO:
“International Association for the Study of Lung Cancer JTO SUPE_R trial sheds light on surveillance imaging for Stage IA-IIIC NSCLC
In this multicenter randomized trial (stage IA–IIIC NSCLC), patients were followed with either contrast-enhanced CT or [18F]FDG PET/CT after curative-intent treatment.
Key findings:
- Recurrence rate: ~22% in both arms
- Curative salvage possible in 48% of recurrences — identical between PET and CT
- PET detected more scheduled recurrences (90% vs 77%)
- No significant difference in TTR (HR 1.12) or OS (HR 0.97)
Bottom line: Routine PET/CT surveillance didn’t improve curative salvage, time to recurrence, or survival over standard contrast CT!”
Title: Surveillance With Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography of Patients With Stage I-to-III Lung Cancer After Completion of Curative treatment (SUPE_R): A Randomized Controlled Trial
Authors: Kasper Foged Guldbrandsen, Martin Bloch, Kristin Skougaard, Lise Barlebo Ahlborn, Erik Jakobsen, Anette Højsgaard, Rene Horsleben Petersen, Lars Borgbjerg Møller, Morten Dahl, Boe Sandahl Sorensen, Malene Støchkel Frank, Jeanette Haar Ehlers, Martin Krakauer, Peter Michael Gørtz, Elisabeth Albrecht-Beste, Julie Marie Grüner, Zaigham Saghir, Joan Fledelius, Anne Lerberg Nielsen, Paw Christian Holdgaard, Søren Steen Nielsen, Mette Pøhl, Svetlana Borissova, Lotte Holm Land, Charlotte Kristiansen, Tine McCulloch, Lise Saksø Mortensen, Hanne Marie Nellemann, Malene Søby Christophersen, Ole Hilberg, Thor Lind Rasmussen, Signe Høyer Simonsen Schwaner, Christian B. Laursen, Uffe Bodtger, Liza Sopina, Markus Nowak Lonsdale, Christian Niels Meyer, Oke Gerke, Jann Mortensen, Torben Riis Rasmussen, Barbara Malene Fischer.
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