John Lewis Shares Article on Metastatic Cancer Progression Study
John Lewis, Bird Dogs Chair in Translational Oncology at University of Alberta, shared a post on LinkedIn:
“Metastasis kills 90% of cancer patients – which is why, to design better treatments, we need to better understand how cancer cells move and invade through the body.
I’m excited to share our new article in Nature Materials studying metastatic cancer progression – a wonderfully productive collaboration with Konstantinos Konstantopoulos (The Johns Hopkins University), Panagiotis Mistriotis (Auburn University), Petr Kalab and many others.
Check out co-author Konstantin Stoletov‘s intravital imaging videos showing how cancer cells ‘squeeze’ through live tissue (Supplementary Materials).
Citation: Tran, A.T., Wisniewski, E.O., Mistriotis, P. et al. Cytoplasmic anillin and Ect2 promote RhoA/myosin II-dependent confined migration and invasion. Nat. Mater. (2025).
Title: Cytoplasmic anillin and Ect2 promoteRhoA/myosin II-dependent confined migration and invasion
Authors: Avery T. Tran, Emily O. Wisniewski, Panagiotis Mistriotis, Konstantin Stoletov, Maria Parlani, Alice Amitrano, Brent Ifemembi, Se Jong Lee, Kaustav Bera, Yuqi Zhang, Soontorn Tuntithavornwat, Alexandros Afthinos, Alexander Kiepas, Bhawana Agarwal, Sanjiban Nath, John J. Jamieson, Yi Zuo, Daniel Habib, Pei-Hsun Wu, Stuart S. Martin, Sharon Gerecht, Luo Gu, John D. Lewis, Petr Kalab, Peter Friedl, Konstantinos Konstantopoulos
You can read the Full Article on Nature Materials
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