Nakul Shah/X
Jun 25, 2025, 15:25
Nakul Shah: Our Latest Review on Precision Oncology is out in The Oncologist
Nakul Shah, Oncology Fellow at MD Anderson Cancer Centre, shared on X:
“Our latest review on precision oncology is out
For tumor-agnostic approvals we assess:1. Efficacy by tumor-type
2. Limitations, toxicity, and resistance
3. Updated trial and real-world evidence
4. Future exciting targets
For each tumor-agnostic approval, we review the indication, mechanism of action, and common toxicities that were observed. We also show the observed response rates by cancer type before FDA approval and with updated data from clinical trials an real-world studies.
We see it is important to take caution when interpreting response rates in cancer types with limited numbers in initial reports basket trials. This trend can clearly be seen for pancreatic cancer in the pembrolizumab and dostarlimab trials.
Exciting future targets and therapeutic agents for tumor-agnostic approvals we highlight include:
1) HER2 amplifications and HER2/EGFR mutations
-Zanidatamab
-Disitamab Vedotin
-Tucatinib + Trastuzumab
-Zongertiib
-BAY 2927088
2) KRAS mutations and pan-RAS alterations
-Adagrasib
-Sotorasib
-Divarasib
-Elironrasib
-RMC-6236 (pan-RAS)
3) TP53 Y220C: Rezatapopt
4) FGFR Alterations: Erdafitinib
5) MTAP Loss: AMG 193
6) NRG1 fusions: Zenocutuzumab and SeribantumabVery thankful for the invaluable mentorship of Dr. Funda Meric-Bernstam! Also grateful to the reviewers and to be published in The Oncologist. Excited to see future developments in precision oncology to continue to increase options and improve outcomes for patients.”
Title: The present and future of precision oncology and tumor-agnostic therapeutic approaches
Authors: Nakul M Shah, Funda Meric-Bernstam
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