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Raffaele Colombo: Sacituzumab Tirumotecan Versus Docetaxel in EGFR-Mutated Advanced NSCLC

Raffaele Colombo/LinkedIn

Jun 12, 2025, 10:54

Raffaele Colombo: Sacituzumab Tirumotecan Versus Docetaxel in EGFR-Mutated Advanced NSCLC

Raffaele Colombo, Associate Director of Medicinal Chemistry at Zymeworks, posted on X:

“OptiTROP-Lung03 published on The BMJ: sacituzumab tirumotecan (sac-TMT) versus docetaxel for previously treated EGFR-mutated advanced NSCLC.

sac-TMT vs docetaxel
ORR: 45% vs 16%
PFS: 6.9 vs 2.8 months
OS: NR, HR=0.49

(data also presented at ASCO25).”

Title: Sacituzumab tirumotecan versus docetaxel for previously treated EGFR-mutated advanced non-small cell lung cancer: multicentre, open label, randomised controlled trial

Authors: Wenfeng Fang, Xingya Li, Qiming Wang, Xiangjiao Meng, Wei Zheng, Longhua Sun, Wenxiu Yao, Wu Zhuang, Yun Fan, Minglei Zhuo, Yongzhong Luo, Zhiye Zhang, Xia Song, Runxiang Yang, Jiacheng Yang, Xiaoping Jin, Yina Diao, Junyou Ge, Li Zhang

Read The Full Article at The BMJ.

Raffaele Colombo: Sacituzumab Tirumotecan Versus Docetaxel in EGFR-Mutated Advanced NSCLC

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