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Amol Akhade: First and Only Approved 1st-Line Immunotherapy For Advanced SCAC (Anal Cancer) in the U.S.
Amol Akhade/hiranandanihospital.org
May 17, 2025, 06:57

Amol Akhade: First and Only Approved 1st-Line Immunotherapy For Advanced SCAC (Anal Cancer) in the U.S.

Amol Akhade, Senior Consultant Medical Oncologist and Hemato-Oncologist at Suyog Cancer Clinics and Reliance Hospitals shared a post on X:

“FDA approves Zynyz® (retifanlimab-dlwr)
  •  First and only approved 1st-line immunotherapy for advanced SCAC (anal cancer) in the U.S.Mechanism:Retifanlimab is a PD-1 inhibitor, restoring T-cell–mediated anti-tumor immunity in HPV-driven tumors.Backed by POD1UM-303 / InterAACT2
  • PFS: 9.3 vs 7.4 mo
  • OS: +6.2 mo | p = 0.0273
  • 37% ↓ risk of progression or death
  •  Combo: Zynyz + carbo/pacli
  •  Also approved as monotherapy post platinumA big step forward in GI immunotherapy!”
Amol Akhade cancer FDA OncoDaily Oncology Zynyz
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