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Sylvester Launches MAC 3 to Tackle Kidney Cancer Through Metabolic Research and Diet
Apr 17, 2025, 11:40

Sylvester Launches MAC 3 to Tackle Kidney Cancer Through Metabolic Research and Diet

Sylvester Comprehensive Cancer Center shared on LinkedIn:

“Renal cell carcinoma, the most common type of kidney cancer, has distinct metabolic traits. To tackle this uniquely behaving cancer, a multidisciplinary team at Sylvester is taking an innovative approach.

Backed by a Sylvester Team Science Award, the researchers will study the cancer’s metabolism through detailed lab and clinical research. Their goal: to better understand these metabolic drivers and introduce a cutting-edge dietary intervention for patients.

Tracy Crane, is leading the new program, Metabolism And renal Cancer (MAC 3), along with Dr. David Lombard, co-leader of Sylvester’s Cancer Epigenetics Program and Dr. Scott Welford, co-leader of the Tumor Biology Program. The researchers will use a large database built by Dr. Jaime Merchan and his colleagues.

Through this collaborative project, Sylvester researchers will:

  • Study the details of renal cell carcinoma lipids.
  • Uncover how circadian clock genes may contribute to the disease.
  • Analyze how body composition impacts response to treatment.
  • Test intermittent fasting in a group of newly diagnosed patients.

Read about a historic first at Sylvester: a team of basic scientists, translational researchers and clinical experts uniting to lead high-quality research into the tumor metabolism of kidney cancer.”