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Oliver Maracic: Avutometinib + Defactinib in Recurrent Low-Grade Serous Ovarian Cancer LGSOC
baybiosciences.com
Mar 18, 2025, 12:43

Oliver Maracic: Avutometinib + Defactinib in Recurrent Low-Grade Serous Ovarian Cancer LGSOC

Oliver Maracic, Investor, shared a post on LinkedIn:

“Avutometinib + Defactinib in Recurrent Low-Grade Serous Ovarian Cancer LGSOC (ENGOT-ov60/GOG-3052/RAMP 201): Dose Intensity and Subgroup Analysis

In KRASm patients,

– ORR was 47% (no prior MEK inhibitor, n=45) vs 33% (prior MEK inhibitor, n=12),
– 53% (no prior bevacizumab, n=34) vs 30% (prior bevacizumab, n=23),
– 49% (1-3 prior therapies, n=35) vs 36% (>3 prior therapies, n=22).

In KRAS wild-type patients,

– ORR was 18% (no prior MEK inhibitor, n=39) vs 15% (prior MEK inhibitor, n=13),
– 25% (no prior bevacizumab, n=20) vs 13% (prior bevacizumab, n=32),
– 21% (1-3 prior therapies, n=28) vs 13% (>3 prior therapies, n=24).”

Oliver Maracic

Avutometinib + Defactinib cancer Oliver Maracic OncoDaily Oncology Ovarian Cancer
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