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Paola Tello Valverde: The significance of hyperthermia in postoperative re-irradiation for patients with locally recurrent breast cancer
Mar 9, 2025, 14:06

Paola Tello Valverde: The significance of hyperthermia in postoperative re-irradiation for patients with locally recurrent breast cancer

Paola Tello Valverde, Co-founder of Jump18-Aruba Childhood Obesity Prevention Program, shared a post on LinkedIn about a paper she co-authored with colleagues published in International Journal of Radiation Oncology, Biology, Physics:

“I am delighted to share that we have reached a significant milestone.

One of my most important investigations, ‘The probability of locoregional control in patients with locoregional recurrent breast cancer treated with postoperative re-irradiation and hyperthermia (RADHY): A continuous thermal dose-effect relationship’, has been recently published in the esteemed IJROBP The Red Journal.

The study establishes a consistent thermal dose-effect relationship, offering valuable insights into the effectiveness of this treatment approach for patients who underwent postoperative re-irradiation combined with hyperthermia.

A significant relationship was observed between an increased thermal dose and an improved locoregional control, varying from ~44% to -98% at 5 years, underscoring the importance of ensuring adequate thermal dose.

This finding reinforces the significance of hyperthermia in enhancing the potent sensitizing effect of postoperative re-irradiation for patients with locally recurrent breast cancer.

I want to express my deepest gratitude to all my co-authors Konstantinos Pateras, Akke Bakker, Polychronis Kostoulas, Willemijn Kolff, Petra Kok, Geertjan van Tienhoven, my promoter Ben Slotman and my co-promoter Hans Crezee. Thank you all so much for your support and collaboration.”

“The probability of locoregional control in patients with locoregional recurrent breast cancer treated with postoperative re-irradiation and hyperthermia (RADHY): A continuous thermal dose-effect relationship”

Authors: Paola Tello Valverde, Akke Bakker, Petra Kok, Willemijn Kolff, Geertjan van Tienhoven, Polychronis Kostoulas, Ben Slotman, Konstantinos Pateras, and Hans Crezee.

Paola Tello Valverde: The significance of hyperthermia in postoperative re-irradiation for patients with locally recurrent breast cancer