![Pure Biologics to test molecule PBA-0405 in project PB004 in a Phase 0 clinical trial in patients with solid tumors – The Antibody Society](https://oncodaily.com/pub/uploads/2023/12/The-Antibody-Society.jpg)
Pure Biologics to test molecule PBA-0405 in project PB004 in a Phase 0 clinical trial in patients with solid tumors – The Antibody Society
The Antibody Society shared on their LinkedIn page:
“In an unusual (to us anyway) move, Pure Biologics has applied to the U.S. Food and Drug Administration for approval to test molecule PBA-0405 (exploratory Investigational New Drug; eIND), the lead candidate in project PB004 in a Phase 0 clinical trial in patients with solid tumors.
Project PB004 involves the development of a novel therapeutic molecule in the format of an afucosylated IgG1 class antibody to stimulate the immune response of NK cells against tumor cells bearing the tumor antigen ROR-1, leading to their direct killing by an antibody-dependent cellular cytotoxicity mechanism.
The PB004 molecule is being developed for the treatment of solid tumors, including triple-negative breast cancer, as well as for the treatment of selected hematological malignancies, including chronic lymphocytic leukemia, among others.
The inclusion of a Phase 0 in an antibody development program is not common.
We look forward to hearing about study results.”
For submissions click here.
Source: The Antibody Society/LinkedIn
-
ASCO Annual Meeting
May 30 - June 4, 2024
-
Yvonne Award 2024
May 31, 2024
-
OncoThon 2024, Online
Feb. 15, 2024
-
Global Summit on War & Cancer 2023, Online
Dec. 14-16, 2023