Yan Leyfman: Off-the-shelf CAR T cells could be a viable option for R/R T-cell Lymphoma
Yan Leyfman, Co-founder and executive director of MedNews Week, shared an article Swaminathan P. Iyer and colleagues authored on LinkedIn:
“New study spearheaded by researchers from MD Anderson Cancer Center and Memorial Sloan Kettering Cancer Center on CTX130, a CAR T-cell therapy for relapsed/refractory T-cell lymphoma, has been completed across the USA, Australia, and Canada. The phase 1 trial included 39 heavily pre-treated patients.
Key Findings:
Safety: Manageable, with cytokine release syndrome being the most common side effect (67% of patients).
Efficacy: 46.2% of patients showed an objective response, with improved results at higher doses (51.6%).
This study indicates that off-the-shelf CAR T cells could be a viable option. Next, CTX131, an enhanced version, is in development.”
Authors: Swaminathan P. Iyer et al.
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