Impact of Breast Cancer Systemic Therapies on Fertility
Jame Abraham, Chairman of the Department of Hematology and Medical Oncology at Cleveland Clinic, shared an article led by Jasmin Hundal on X about the effects of breast cancer treatments on fertility in young women.
Impact of Breast Cancer Systemic Therapies on Fertility.
Authors: Jasmin Hundal and Halle Moore
This review focuses on the effects of breast cancer treatments on fertility in young women and the available strategies for fertility preservation.
It delves into how chemotherapy, hormonal therapies, and newer targeted treatments, such as PARP inhibitors and CDK4/6 inhibitors, impact ovarian function and fertility. The paper underscores the importance of considering fertility preservation as an integral part of oncology care for young patients facing breast cancer.
Recent findings emphasize the significant risk these treatments pose to ovarian reserve, and explore options like treatment interruptions, with studies such as the POSITIVE trial shedding light on the safety of pregnancy after breast cancer treatment. The review calls for personalized fertility preservation plans to optimize outcomes for young women, while ongoing research aims to refine strategies to better support informed decision-making and improve long-term quality of life for breast cancer survivors.
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