Anirban Maitra: How do Pancreatic Cancer cells “tolerize” themselves to high levels of viral repeat RNA expression
Anirban Maitra, Director of the Sheikh Ahmed Pancreatic Cancer Research Center, shared a paper Eunae You and colleagues authored on X:
“How do Pancreatic Cancer cells “tolerize” themselves to high levels of viral repeat RNA expression, a near universal phenomenon in this disease. Why aren’t these cells eliminated by an antiviral innate immune response?
In this Cancer Discovery paper, David Ting and Benjamin D. Greenbaum identify a pivotal non-canonical role for Orf1p (the major protein coded by LINE-1 retrotransposin) in repeat “masking”, creating a permissive tumor growth milieu. Loss of Orf1p allows a productive innate response against cancer cells & also enhances the response to KRASi.”
LINE-1 ORF1p Mimics Viral Innate Immune Evasion Mechanisms in Pancreatic Ductal Adenocarcinoma
Authors: Eunae You et al.
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