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Pembrolizumab versus chemotherapy in MSI or dMMR metastatic colorectal cancer
Dec 5, 2024, 09:26

Pembrolizumab versus chemotherapy in MSI or dMMR metastatic colorectal cancer

Arndt Vogel shared on X:

Pembrolizumab versus chemotherapy in MSI or dMMR mCRC

5-year follow-up from KEYNOTE-177

mPFS 16.5 vs 8.2 mo

5-yr OS rate 55% vs 44%

Excellent outcome in responders

30% non-responder concerning > Nivo/Ipi?.

Pembrolizumab Versus chemotherapy in microsatellite instability–high or mismatch repair–deficient metastatic colorectal cancer: 5-year follow-up from the randomized phase 3 KEYNOTE-177 study – Annals of Oncology

Authors: T. André, K. Shiu, T.W. Kim, B.V. Jensen, L.H. Jensen, C.J.A. Punt, D. Smith, R. Garcia-Carbonero, J. Alcaide-Garcia, P. Gibbs, C. de la Fouchardiere, F. Rivera, E. Elez, D.T. Le, T. Yoshino, Y. Zuo, D. Fogelman, D. Adelberg, L.A. Diaz, Jr.

Pembrolizumab versus chemotherapy in MSI or dMMR metastatic colorectal cancer

Pembrolizumab versus chemotherapy in MSI or dMMR metastatic colorectal cancer

Arndt Vogel, MD, is a Managing Senior Consultant and a Professor in the Department of Gastroenterology, Hepatology, and Endocrinology at Hannover Medical School. Leading the GI-Cancer Center and the Center for Personalized Medicine, his research focuses on translational and clinical studies in gastrointestinal cancer. He’s actively engaged in various societies including ESMO, ASCO, and EASL. Additionally, he chairs the Hepatobiliary Cancer Study Group of the AIO, contributing significantly to clinical oncology in Germany. Within ESMO, he serves on the Guidelines Steering Committee.