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Nov 16, 2024, 09:51

Steven Artandi: Discovery of Persistent ecDNA Transcription During Cell Division

Steven Artandi, Director of the Stanford Cancer Institute, shared a paper by King L. Hung et al. on X, adding the following:

“SCI members Howard Y. Chang, Mischel Lab & collaborators discovered that ecDNA transcription persists during cell division, allowing ecDNAs to stay interconnected, & segregating together as multi-circle units into daughter cells.”

Coordinated inheritance of extrachromosomal DNAs in cancer cells

Authors: King L. Hung, Matthew G. Jones, Ivy Tsz-Lo Wong, Ellis J. Curtis, Joshua T. Lange, Britney Jiayu He, Jens Luebeck, Rachel Schmargon, Elisa Scanu, Lotte Brückner, Xiaowei Yan, Rui Li, Aditi Gnanasekar, Rocío Chamorro González, Julia A. Belk, Zhonglin Liu, Bruno Melillo, Vineet Bafna, Jan R. Dörr, Benjamin Werner, Weini Huang, Benjamin F. Cravatt, Anton G. Henssen, Paul S. Mischel & Howard Y. Chang

cancer cancer progression Cell Division ecDNA Howard Y. Chang mischelLab multi-circle units Nature OncoDaily oncogenes Oncology Steven Artandi therapy resistance transcription Tumor Heterogeneity

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