Understanding Double-Strand Breaks in the Formation of ecDNA

Steven Artandi, Director of Stanford Cancer Institute and Professor at Stanford University School of Medicine, shared a recent article by John C. Rose on X:

“SCI members Howard Chang, Paul Mischel, and others found support a model of ecDNA formation in which double strand break ends dissociate from their legitimate ligation partners prior to joining of illegitimate ends to form the ecDNA and excision scar.

Title: Disparate pathways for extrachromosomal DNA biogenesis and genomic DNA repair.

Authors: John C. Rose, Julia A. Belk, Ivy Tsz-Lo. Wong, Jens Luebeck, Hudson T. Horn, Bence Daniel, Matthew G. Jones, Kathryn E. Yost, King L. Hung, Kevin S. Kolahi, Ellis J. Curtis, Calvin J. Kuo, Vineet Bafna, Paul S. Mischel and Howard Y. Chang