Insight

Genetic interactions that shape tumorigenesis

Photo taken from Alberto Diaz-Jimenez/LinkedIn

Sep 2, 2024, 17:09

Genetic interactions that shape tumorigenesis

Vincent Lam, medical oncologist at Johns Hopkins Kimmel Cancer Center, shared a post by Monte Winslow’s Lab, on X:

“Cool stuff from Monte Winslow’s Lab further suggesting that variant 3 is more oncogenic; perhaps other ‘short’ EML4-ALK fusions too.
Also, tumor suppressors have variant-specific impact.
On the road towards personalizing ALK therapy…”

Quoting for Monte Winslow’s Lab post:

“Amazing collaboration between Emily Shuldiner and Alberto Diaz using somatic genome editing to model 60 different genotypes of EML4-ALK lung cancer. Genetics say that Variant 1 and Variant 3 should be considered distinct oncogenes.

EML4-ALK variant-specific genetic interactions shape lung tumorigenesis

Authors: Alberto Diaz-Jimenez, Emily G. Shuldiner, Kalman Somogyi, Oscar Gonzalez, Filiz Akkas, Christopher W. Murray, Laura Andrejka, Min K. Tsai, Benedikt Brors, Smruthy Sivakumar, Saumya D. Sisoudiya, Ethan S. Sokol, Dmitri A. Petrov, Monte M. Winslow, Rocio Sotillo.”

Genetic interactions that shape tumorigenesis

Source: Vincent Lam/X and Monte Winslow’s Lab/X

Alberto Diaz Alberto Diaz-Jimenez ALK+ lung cancer Benedikt Brors cancer Christopher W. Murray Dmitri A. Petrov Emily G. Shuldiner Emily Shuldiner EML4- ALK Ethan S Sokol Filiz Akkas Kalman Somogyi Laura Andrejka Min K. Tsai Monte M. Winslow Monte Winslow's lab OncoDaily Oncology Oscar Gonzalez Rocio Sotillo Saumya D. Sisoudiya Smruthy Sivakumar Vincent Lam

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