How can we identify a gene signature of metastatic potential?

Anirban Maitra shared on X:

“Preprint from Reza Kalhor (in collaboration with Elana J Fertig, Hani Goodarzi et al): Identifying a gene signature of metastatic potential by linking pre-metastatic state to ultimate metastatic fate

‘Identifying a gene signature of metastatic potential by linking pre-metastatic state to ultimate metastatic fate‘

Authors: Jesse S Handler, Zijie Li, Rachel K Dveirin, Weixiang Fang, Hani Goodarzi, Elana J Fertig, Reza Kalhor

Interesting study that uses barcoded single cell isolates of murine Pancreatic Cancer cells to identify ‘metastatic high’ and ‘metastatic low’ transcriptional modules in vivo. The phrase ‘pre-metastatic state’ is used to describe the presence of said modules in primary cancers prior to metastasis (not to be confused with ‘pre-metastatic niche’). Some surprising candidates in the ‘low metastasis’ modules but read the preprint for an explanation.”

Source: Anirban Maitra/X

Dr. Anirban Maitra serves as Professor of Pathology and Translational Molecular Pathology at UT MD Anderson Cancer Center since August 2013, and directs the Sheikh Ahmed Pancreatic Cancer Research Center. He leads an NCI-funded laboratory dedicated to pancreatic cancer research, focusing on genetics and molecular pathology in human and mouse models. His research aims to advance early detection and interception strategies to enhance patient survival rates in pancreatic cancer.