The genomic landscape of 2023 colorectal cancers
Wafik S. El-Deiry shared on LinkedIn:
“Important paper on CRC (colorectal cancer)
The genomic landscape of 2,023 colorectal cancers
Authors: Alex J. Cornish, Andreas J. Gruber, Ben Kinnersley, Daniel Chubb, Anna Frangou, Giulio Caravagna, Boris Noyvert, Eszter Lakatos, Henry M. Wood, Steve Thorn, Richard Culliford, Claudia Arnedo-Pac, Jacob Househam, William Cross, Amit Sud, Philip Law, Maire Ni Leathlobhair, Aliah Hawari, Connor Woolley, Kitty Sherwood, Nathalie Feeley, Güler Gül, Juan Fernandez-Tajes, Luis Zapata, Ludmil B. Alexandrov, Nirupa Murugaesu, Alona Sosinsky, Jonathan Mitchell, Nuria Lopez-Bigas, Philip Quirke, David N. Church, Ian P. M. Tomlinson, Andrea Sottoriva, Trevor A. Graham, David C. Wedge and Richard S. Houlston.
‘Integrated analyses identify more than 250 putative CRC driver genes, many not previously implicated in CRC or other cancers, including several recurrent changes outside the coding genome.’
‘define four new common subgroups of microsatellite-stable CRC based on genomic features and show that these groups have independent prognostic associations’
‘cancers with both microsatellite and chromosomal instability’
‘role of Escherichia coli pks+ colibactin in rectal cancers and the importance of the SBS93 signature, which suggests that diet or smoking is a risk factor’
‘Immune-escape driver mutations are near-ubiquitous in hypermutant tumours and occur in about half of microsatellite-stable CRCs’
The article makes a case for whole genome sequencing in CRC.”
Source: Wafik S. El-Deiry/LinkedIn
Wafik El-Deiry, MD, PhD, FACP, FRSM, is the Associate Dean for Oncologic Sciences at the Warren Alpert Medical School and Director of the Legorreta Cancer Center at Brown University and Director of the Joint Program in Cancer Biology at Brown University and affiliated hospitals.
He is the Editor in Chief at Oncotarget. Dr. El-Deiry discovered p21(WAF1) as a p53 target gene, cell cycle inhibitor, and tumor suppressor that explained the mammalian cell stress response. Dr. El-Deiry’s research is focused on mechanisms of therapy resistance with major efforts in drug discovery and development.
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