Andy Hahn: Body composition’s influence on the therapeutic index with ARSI
Andy Hahn, Genitourinary Medical Oncologist at MD Anderson Cancer Center, shared a thread on X:
“Tweetorial for our latest paper on body composition’s influence on the therapeutic index with ARSI in Prostate Cancer and Prostatic Diseases. This work was supported by a Conquer Cancer YIA and established our ongoing research program.
Steroidogenesis has roles in muscle, fat, and PCa. We studied how inherited variants in steroidogenic genes influenced body composition at time of mCRPC. We found differences in body composition by genotype in AKR1C3, CYP17A1, and SRD5A2 SNPs.
We measured body composition using CTs before tx with ADT + apa + abi (AAPA) in 186 men with mCRPC. We found that elevated subQ and visceral fat were associated with improved PSA response to AAPA and showed how body composition groupings influenced response.
Last, subQ and visceral fat had positive correlations with leptin but not most of the remaining adipokines we tested.
Source: Andy Hahn/X
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