Obrixtamig Plus Ezabenlimab Shows Activity in DLL3-Positive SCLC

Obrixtamig Plus Ezabenlimab Shows Activity in DLL3-Positive SCLC

What Are Experts Saying About The  Trial?

Dr David Planchard- Prof at University Paris Sacly- Head of Thiracic Cancer Group/Gustave Roussy write in linkdin

Congrats #JulienMazieres on the great presentation and the encouraging results for our lung NETs. Really impressive study testing the combination in all the different neuroendocrine tumor subtypes! #SCLC #ELCC2026

Key Takeaway

The trial demonstrates that obrixtamig plus ezabenlimab shows manageable safety and encouraging efficacy in DLL3-positive SCLC, particularly at higher dose levels.

This approach highlights the potential of DLL3-targeted immunotherapy combined with checkpoint inhibition as a next-generation strategy in small cell lung cancer.

You can read full abstract here