Young Kwang Chae, Professor of Medicine at Northwestern University, shared on X:
“Thrilled to present our latest multi-institutional pan-cancer research at ESMO26!
Can AI–driven assessment of Tertiary Lymphoid Structures (TLS) refine immunotherapy outcomes beyond standard TIL density?
Our analysis of n=2,023 ICI-treated patients shows:
- Added Prognostic Value: TLS presence predicts significantly longer PFS & OS, particularly within the TIL-low subgroup.
- Beyond Lung Cancer: TLS prognostic significance remains prominent across non-lung solid tumors (n=755).
- Dual Blockade: In anti-PD-1/CTLA-4 combination therapy, TLS presence (rather than TIL density) emerged as a key determinator of survival benefit.
Combining spatial AI quantification of TLS + TIL density via Lunit H&E analysis enables refined biomarker stratification across diverse tumor types.
Grateful to our outstanding collaborators including Dr. Yoojoo Lim!”
Other articles about Tertiary Lymphoid Structures on OncoDaily.