Yan Leyfman: New Research on Trogocytosis in CAR-T Cells
Yan Leyfman, Co-founder and executive director of MedNews Week, shared an article by Stefano Barbera, et al. on LinkedIn:
“New Research on Trogocytosis in CAR-T Cells.
A recent study from Uppsala University reveals that T cells can exchange chimeric antigen receptors (CARs) through trogocytosis, a process where membrane proteins are transferred between cells during contact.
Here are the key findings:
T cells gain the ability to respond to tumor antigens by acquiring CARs, leading to enhanced cytotoxic activity against target cells.
The exchange mechanism is governed by the transmembrane domain of the protein, not requiring a specific binding partner on the recipient cell.
This discovery could influence future CAR-T cell therapy designs, providing insights into controlling immune responses.
How might this impact future cancer treatments?”
Trogocytosis of chimeric antigen receptors between T cells is regulated by their transmembrane domains.
Authors: Stefano Barbera, et al.
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