Thomas Ichim, President and Chief Scientific Officer at Immorta Bio, shared a poll about mRNA cancer vaccine with options ‘good’ and ‘bad’ to choose by voters in a post on X:
“Metformin can alter human tumor immunity without directly reducing tumor proliferation.
In a phase II esophageal cancer study, 250 mg/day increased intratumoral CD8 T cells, B cells and antitumor-associated macrophages, despite no detectable change in Ki67 or apoptosis.”
Title: Low-Dose Metformin Reprograms the Tumor Immune Microenvironment in Human Esophageal Cancer: Results of a Phase II Clinical Trial
Authors: Shuhong Wang, Yusheng Lin, Xiao Xiong, Lu Wang, Yi Guo, Yuping Chen, Shaobin Chen, Geng Wang, Peng Lin, Hongcai Chen, Sai-Ching Jim Yeung, Edwin Bremer, Hao Zhang
You can read more articles about esophageal cancers on OncoDaily:
Top Gastroesophageal Cancer Updates From ESMO 2026
