Sung-Min Hwang, Assistant Professor at Ulsan National Institute of Science and Technology, shared on LinkedIn:
“Excited to share our new invited review, published today in Experimentaland Molecular Medicine (Springer Nature) ‘Decoding T cell exhaustion in the tumour microenvironment‘
T cell exhaustion is not simply a dysfunctional endpoint, but a dynamic differentiation landscape shaped by persistent antigen stimulation, metabolic stress, epigenetic remodeling, and spatial organization within the tumor microenvironment.
In this review, we discuss how progenitor exhausted T cells (TPEX) transition toward terminal exhaustion, how distinct tumor niches regulate these cell states, and why preserving stem-like T cell populations may be critical for achieving durable responses to cancer immunotherapy.
My sincere thanks to the editors for the invitation and congratulations to Jin A Park and Jeyeon Im for their great work on putting this review together!
We look forward to sharing some exciting new findings on exhausted T cells very soon.”
Title: Decoding T cell exhaustion in the tumour microenvironment
Authors: Jin A Park, Jeyeon Im and Sung-Min Hwang
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