Shreya Gandhi, MD-PhD student and researcher in neuro-oncology at Mayo Clinic School of Medicine, shared a post on X:
“Proud to share our work identifying ICAM1 as a marker of an immune-remodeled glioblastoma ecosystem associated with altered cellular composition and malignant states (Editor – Neuro-Oncology Advances).
Grateful to Sheila Mansouri, Gelareh Zadeh for their mentorship and to all co-authors involved!
We show that ICAM1 marks an immune-remodeled glioblastoma ecosystem, that ICAM1 promoter methylation, RNA, and protein levels are prognostic biomarkers, and that our Clinical-Imaging-Molecular (CIM) model enables outcome prediction without advanced molecular profiling.”
Title: Intercellular adhesion molecule 1 links glioblastoma biology to a scalable prognostic model integrating clinical, imaging, and molecular features
Authors: Shreya Gandhi, Beatriz Ocaña-Tienda, Manuel M Bettencourt, Olivia S Singh, Kaviya Devaraja, Emily R Irish, David Molina-García, Shirin Karimi, Yasin Mamatjan, Julio Sosa, Ian McIntyre, Andrew F Gao, Julián Pérez-Beteta, Ana Ramos-González, Aurelio Hernández-Laín, Beatriz Asenjo, María Pino Flores-Rial, Pilar Sánchez-Gómez, Kenneth D Aldape, Carlos Santos, Katharine J Drummond, Ian F Parney, Carlos Velasquez, Alireza Mansouri, Victor M Pérez-García, Gelareh Zadeh, Sheila Mansouri
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